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| CAVALCANTI,PAULO M.S.; MARTINS,MARIA DO CARMO C.; NUNES,PAULO H.M.; ALVES FILHO,FRANCISCO C.; SILVA,JANYERSON D.P.; CAVALCANTI,SUZANA M.G.. |
| Abstract This study investigated the effects of the ethanolic extract from the bark of Combretum leprosum (ECL) on intestinal transit and castor-oil induced diarrhea in mice. The oral administration of ECL (750 and 1000 mg/kg) slowed intestinal transit (ID50 of 455 mg/kg). The ECL (250-1000 mg/kg) reduced castor-oil induced diarrhea, in a time- and dose-dependent manner (p < 0.05). To determine if antidiarrheal effect of ECL involves α2-adrenergic or opioid receptor activation, the mice were pretreated with antagonists of these receptors, yohimbine or naloxone respectively. None of these drugs inhibited the antidiarrheal effect of ECL. To test if antidiarrheal effect of ECL is due to an antisecretory action, we realized the enteropooling assay on rats.... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Combretum leprosum; Antidiarrheal effect; Medicinal plants; Polyphenols; Intestinal transit; Enteropooling. |
| Ano: 2019 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0001-37652019000100701 |
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| Lopes,L.S.; Marques,R.B.; Pereira,S.S.; Ayres,M.C.C.; Chaves,M.H.; Cavalheiro,A.J.; Vieira Júnior,G.M.; Almeida,F.R.C.. |
| Previous studies on Combretum leprosum, a tree growing in the Northeastern states of Brazil, have shown antinociceptive effects of the ethanol extract of its leaves and bark, but studies examining its constituents are rare. The objective of this study was to evaluate the antinociceptive effect of the hydroalcoholic fraction (HF) of one of its constituents, the flavonoid (-) epicatechin (EPI), administered orally to mice (20-30 g) in models of chemical nociception, and the possible mechanisms involved. Different doses of HF (62.5 to 500 mg/kg) and EPI (12.5 to 50 mg/kg) were evaluated in models of abdominal writhing, glutamate, capsaicin, and formalin in animals pretreated with different antagonists: naloxone, ondansetron, yohimbine, ketanserin, pindolol,... |
| Tipo: Info:eu-repo/semantics/article |
Palavras-chave: Combretum leprosum; Epicatechin; Antinociceptive; Serotonin; Nitric oxide. |
| Ano: 2010 |
URL: http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2010001200008 |
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| ROGERIO, M. C. P.; GUEDES, L. F.; ALVES, A. A.; POMPEU, R. C. F. F.; FERREIRA, M. I. C.; ALVES, F. G. da S.; COSTA, C. dos S.; BOMFIM, M. A. D.; GUEDES, F. L.. |
| Este comunicado técnico tem como objetivo indicar estratégias nutricionais como mitigadoras de gases de efeito estufa, aplicadas em grupos genéticos localmente adaptados ao Semiárido brasileiro. Além disso, objetiva-se reforçar para a comunidade formas e ferramentas tecnológicas para a produção sustentável de ovinos no trópico Semiárido. |
| Tipo: Comunicado Técnico (INFOTECA-E) |
Palavras-chave: Combretum leprosum; Mitigação; Mofumbo; Semiárido; Brasil; Ovino; Mudança Climática; Produção Animal; Alimento Para Animal; Metano; Mucuna Preta; Leguminosa Forrageira; Stizolobium Aterrimum; Caatinga; Sheep; Small ruminants; Greenhouse effect; Greenhouse gases; Ruminant nutrition; Brazil.; Semiarid soils. |
| Ano: 2019 |
URL: http://www.infoteca.cnptia.embrapa.br/infoteca/handle/doc/1117108 |
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